TINAKID (filgrastim) is a 175 amino acid human granulocyte colony-stimulating factor (G-CSF) manufactured by recombinant DNA technology. TINAKID is produced by Escherichia coli (E coli) bacteria into which has been inserted the human granulocyte colony-stimulating factor gene. TINAKID has a molecular weight of 18‚800 daltons. The protein has an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis‚ except for the addition of an N-terminal methionine necessary for expression in E coli. Because TINAKID is produced in E coli‚ the product is non-glycosylated and thus differs from G-CSF isolated from a human cell. TINAKID injection is a sterile‚ clear‚ colorless‚ preservative-free liquid containing filgrastim at a specific activity of 1.0 ± 0.6 x 10 8 U/mg (as measured by a cell mitogenesis assay). The product is available in prefilled syringes. The single-use prefilled syringes contain either 150mcg/0.25 mL.



  • 1) Patients with Cancer Receiving Myelosuppressive Chemotherapy
  • 2) Patients with Acute Myeloid Leukemia Receiving Induction or Consolidation Chemotherapy
  • 3) Patients with Cancer Undergoing Bone Marrow Transplantation
  • 4) Patients Undergoing Autologous Peripheral Blood Progenitor Cell Collection and Therapy
  • 5) Patients with Severe Chronic Neutropenia
  • 6) Patients Acutely Exposed to Myelosuppressive Doses of Radiation (Hematopoietic Syndrome of Acute Radiation Syndrome)

Administration Instructions


It may be administered as a short-term injection within 15 to 30 minutes (chemotherapy-induced neutropenia) or as an injection over 24 hours (bone marrow transplant).


The correct method of subcutaneous injection

  • 1) Choosing the injection site and placing ice in the injection site in order to reduce pain (in the outer part of the arm, the abdomen with a five-centimeter area of ​​the navel, the upper part of the bottom, the middle or front part of the thigh)
  • 2) In order to reduce pain, 30 minutes before the injection put the syringe at room temperature
  • 3) Wash your hands and injection site with warm water and soap
  • 4) Cleaning the injection site with cotton
  • 5) Remove the syringe from the packaging and plastic container and check the appearance of the syringe in terms of cracks, breaks and the absence of the syringe cap.
  • 6) Remove the plastic cap
  • 7) removing air bubbles from the syringe (avoid shaking the syringe)
  • 8) Lifting the skin with one hand
  • 9) Taking the prepared syringe with the other hand and inserting the syringe into the skin at an angle of 90 or 45 degrees and injecting it at a constant speed
  • 10) Take out the syringe slowly and put cotton wool in the injection site
  • 11) Putting the cap on the syringe and throwing it in the trash

Side effects

bone pain, headache, muscle pain, joint pain, diarrhea, hair loss, nausea and vomiting.


  • The medicine should be kept at a temperature of 2 to 8 degrees Celsius (in the refrigerator) and protected from freezing.
  • In case of freezing, the medicine can be defrosted and used only once by putting it in the refrigerator.
  • If the medicine is frozen more than once, it should be thrown away.
  • Keep the medicine in the original box away from light and avoid shaking the medicine.
  • Avoid taking medicines that have been left at room temperature for more than 48 hours.
  • Keep in a safe place and out of reach of children.