TINAPEG (pegfilgrastim) is a covalent conjugate of recombinant methionyl human G-CSF (filgrastim) and monomethoxypolyethylene glycol. Filgrastim is a water-soluble 175 amino acid protein with a molecular weight of approximately 19 kilodaltons (kD). Filgrastim is obtained from the bacterial fermentation of a strain of E coli transformed with a genetically engineered plasmid containing the human G-CSF gene. To produce pegfilgrastim, a 20 kD monomethoxypolyethylene glycol molecule is covalently bound to the N-terminal methionyl residue of filgrastim. The average molecular weight of pegfilgrastim is approximately 39 kD. TINAPEG for manual subcutaneous injection is supplied in 0.6 mL prefilled syringes. The prefilled syringe does not bear graduation marks and is designed to deliver the entire contents of the syringe (6 mg/0.6 mL). The delivered 0.6 mL dose from either the prefilled syringe for manual subcutaneous injection TINAPEG contains 6 mg pegfilgrastim (based on protein weight) in a sterile, clear, colorless, preservative-free solution (pH 4.0) containing acetate (0.35 mg), polysorbate 20 (0.02 mg), sodium (0.02 mg), and sorbitol (30 mg) in Water for Injection, USP.



  • 1) Patients with Cancer Receiving Myelosuppressive Chemotherapy
  • 2) Patients with Hematopoietic Subsyndrome of Acute Radiation Syndrome

Administration Instructions


The correct method of subcutaneous injection

  • 1) Choosing the injection site and placing ice in the injection site in order to reduce pain (in the outer part of the arm, the abdomen with a five-centimeter area of ​​the navel, the upper part of the bottom, the middle or front part of the thigh)
  • 2) In order to reduce pain, 30 minutes before the injection put the syringe at room temperature
  • 3) Wash your hands and injection site with warm water and soap
  • 4) Cleaning the injection site with cotton
  • 5) Remove the syringe from the packaging and plastic container and check the appearance of the syringe in terms of cracks, breaks and the absence of the syringe cap.
  • 6) Remove the plastic cap
  • 7) removing air bubbles from the syringe (avoid shaking the syringe)
  • 8) Lifting the skin with one hand
  • 9) Taking the prepared syringe with the other hand and inserting the syringe into the skin at an angle of 90 or 45 degrees and injecting it at a constant speed
  • 10) Take out the syringe slowly and put cotton wool in the injection site
  • 11) Putting the cap on the syringe and throwing it in the trash

Side effects

  • Each drug, along with its therapeutic effects, may also cause some unwanted side effects. Although all these complications are not seen in one person.
  • Consult your pharmacist or doctor if the following side effects occur: bone pain, headache, muscle pain, joint pain, diarrhea, hair loss, nausea and vomiting.


  • The medicine should be kept at a temperature of 2 to 8 degrees Celsius (in the refrigerator) and protected from freezing.
  • In case of freezing, the medicine can be defrosted and used only once by putting it in the refrigerator.
  • If the medicine is frozen more than once, it should be thrown away.
  • Keep the medicine in the original box away from light and avoid shaking the medicine.
  • Avoid taking medicines that have been left at room temperature for more than 48 hours.
  • Keep in a safe place and out of reach of children.


1) How much and when should Tinapeg be taken?

-The dosage of each drug is ordered by the doctor but usually it is prescribed like:

In patients over 45 kg, A single dose of 6 is administered subcutaneously 24 to 72 hours after each chemotherapy cycle.

Tinapeg should be injected only on the day prescribed by the doctor and should be avoided for 24 hours after the administration of chemotherapy drugs.